Researchers have discovered a surprising change in how cells produce energy in people with depression. Brain and blood cells in young adults with major depressive disorder produced more energy molecules at rest but had trouble increasing energy production when needed. Scientists believe this imbalance may contribute to symptoms such as fatigue and low motivation. The finding could help pave the way for earlier diagnosis and more personalized treatments.

Scientists at the University of Queensland partnered with researchers from the University of Minnesota to examine levels of adenosine triphosphate (ATP) - known as the “energy currency” molecule - in the brains and blood cells of young people with depression.